The action of steroids on glycogen breakdown in surviving muscle.

1. Minced muscle and liver of normal rats produce glycogen from glucose-l-phosphate in vitro. 2. If, after a starvation period, the glycogen content falls below 200 mg./100 g., minced liver and muscle do not produce glycogen from glucose-lphosphate. However, if glycogen is added as well, additional glycogen is produced, just as with pure enzyme solutions. 3. In adrenalectomized, adynamic rats the glycogen content is decreased in liver and muscle, and only if glycogen is added can production ofnew glycogen by minced muscle and liver be observed to occur at the same rate as with normal animals. Thus adrenalectomy does not affect the mechanism responsible for the synthesis of glycogen from glucose-i-phosphate.